08:30 – 08:45

Welcome to ARI Orthopaedics & Davos

10:45 – 11:15

Dirk Bumann (CH)
Phenotyping bacteria in the in vivo environment

11:15 – 11:45

Noreen Hickok (US)
The changing joint environment: bacterial responses

11:45 – 12:00

E Seebach, CE Pérez-Cevallos, KF Kubatzky (DE)
cGAS-STING Pathway in Orthopaedic Infections

12:00 – 12:15

B Pascoe, J Littlefair, SK Sheppard (UK)
Comparative genomics and the evolution of pathogenic staphylococci

14:00 – 14:30

Jim Cassat (US)
Bone appétit: bacterial pathogenesis during Staphylococcus aureus osteomyelitis

14:30 – 15:00

Ute Neugebauer (DE)
Characterization of S. aureus-induced bone deformation using fluorescence and Raman imaging

15:00 – 15:15

H Meghwani, KM Sandercock, KA McDonald, M Saito, R Constantine, S Lenigk, A Rodriguez, JR Owen, SL Kates, EM Schwarz, G Muthukrishnan (USA)
CCL20/CCR6 axis is essential to limiting the disease severity in Staphylococcus aureus osteomyelitis

15:15 – 15:30

Y Ren, KL de Bentley, J Weeks, T Xue, Y Shu, AJ Hui Tay, S Lekkala, SCA Yeh, EM Schwarz, C Xie (USA)
Osseointegration of hydroxy bisphosphonate-conjugated sitafloxacin (HBCS) during skeletal growth and fracture healing in a mice model

16:00 – 16:30

Tom Coenye (BE)
Novel approaches to study biofilm biology in the context of prosthetic joint infections

16:30 – 17:00

Jan-Willem Veening (CH)
Uncovering mechanisms of host-pathogen interactions using CRISPR interference

17:00 – 17:15

JL Hamilton, TM Schmid, J Rhodes, A Markovics, SD Goodman, LO Bakaletz, MA Wimmer (USA)
Titanium coated with anti-DNABII monoclonal antibody disrupts bacterial biofilm

17:15 – 17:30

B Chen, L P Benavente, M Chittò, V Post, C Constant, S Zeiter, P Nylund, M D’Este, M G Moreno, A Trampuz, J Wagemans, R Lavigne, J Onsea, R G Richards, W-J Metsemakers, T F Moriarty (BE/CH)
Carboxymethyl cellulose hydrogel containing phage cocktail and vancomycin for topical delivery against fracture-related infections

17:30 – 17:45

S Cometta, L Chai, DW Hutmacher (AUS)
An in vitro model to study implant-associated biofilms using a GelMA-based 3D microenvironment

08:30 – 09:00

Henny van der Mei (NL)
Bacterial outer membrane vesicles for targeted treatment of bacterial infections

09:00 – 09:30

Xing Wang (CN)
Antimicrobial chiral polymers and carrier free nanodrugs

09:30 – 09:45

G Mannala, M Rupp, N Walter, R Youf, S Bärtl, V Alt, M Riool (DE)
Repetitive combined doses of bacteriophages and gentamicin protect against Staphylococcus aureus implant-related infections in Galleria mellonella

09:45 – 10:00

V Pennone, E Angelini, D Sarlah, AB Lovati (IT)
Synthesis and antibacterial activity of LL-37-derived antimicrobial peptides as potential treatment of orthopaedic infections

10:20 – 10:50

Britt Wildemann (DE)
Bone fracture non-union

10:50 – 11:20

Hamish Simpson (UK)
How infection changes non-union treatment

11:20 – 11:35

K Trenkwalder, S Erichsen, F Weisemann, P Augat, S Hackl (DE)
The diagnosis of low-grade infection in presumed aseptic femoral or tibial shaft nonunion by membrane filtration of sonication fluid

11:35 – 11:50

P Fehrenbach, F Weisemann, C Siverino, K Trenkwalder, L Bürgi, S Hackl, S A. J. Zaat, E C. de Jong T F Moriarty (CH)
Increased number of Th1 cells and monocytes is associated with infected non-union in patients with long bone fracture.

11:50 – 12:20

Andrea Montali (CH)
Translation of infection-focused technologies to the clinic

12:20 – 12:40

Chris Arts (NL)
Material technology to tackle Antimicrobial Resistance; the NWA DARTBAC project

09:00 – 09:30

Sonja Häckel (CH)
Spondylodiscitis and implant-related spinal Infections: Current challenges and needs from a surgeon's perspective

09:30 – 10:00

Shanmughanathan Rajasekaran (IN)
Can sub-clinical infection be cause for disc degeneration and back pain? - Evidence from metagenomic, proteomic and metabolomic studies.

10:00 – 10:15

A Nüesch, E Kanelis, L Alexopoulos, F Williams, B Gantenbein, M Lacey, LC Le Maitre (UK)
Exploring Gram-positive bacteria within the intervertebral disc: what is their potential influence?

10:15 – 10:30

C Feng, C Liu, J Long, Y Zhou, C Li, B Huang (CN)
Comparison of the diagnostic efficacy of blood and tissue metagenomes in primary spinal infection

11:00 – 11:30

Li Zhang (HK)
Micro- and nanorobots for biofilm eradication

11:30 – 12:00

Sabrina Green (BE)
Making antibiotics great again: Phage resistance correlation with resensitivity to antibiotics in pan-resistant P. aeruginosa

12:00 – 12:15

C Siverino, L Gens, M Ernst, T Bucholz, M Windolf, S Zeiter, R G Richards, M Morgenstern, T. F. Moriarty (CH)
Debridement, antibiotics, irrigation, and implant retention in a preclinical model of FRI in sheep

12:15 – 12:30

Y Ren, KL de Bentley, J Weeks, T Xue, Y Shu, AJH Tay, S Lekkala, SA Yeh, EM Schwarz, C Xie
Real-time fluorescent microscopy assessment of PAD4-mediated NETosis and NET degradation by S. aureus nuclease during nidus formation on implants

12:30 – 12:40

Geoff Richards (CH)
Berton Rahn Research Award Introduction

12:40 – 13:10

Edward Schwarz (US) Berton Rahn Research Award winner 2024
Elucidating the osteoimmunology of bone infection and development of a passive immunization for S. aureus osteomyelitis

13:10 – 13:30

Fintan Moriarty / Marco Chittò (CH)
Students awards and conference closing